Among an increasing number of investors and portfolio managers, cryptocurrency is considered a legitimate and distinct asset class. Many institutions are entering the market for varying reasons as they look to diversify their exposure and maximise returns. The investment thesis for the wider crypto market has gathered momentum, however how these large firms enter the market is constantly evolving. Institutions may purchase crypto through an algorithm, gain exposure through derivatives, or invest directly in protocols. There are a host of unique challenges that new entrants must navigate before allocating capital to crypto or DeFi markets. We take a look at the trends of 2021, the performance of this infrastructure to date, and where it can improve to facilitate the next wave of entrants.